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Calcium folinate CAS 1492-18-8

Folinic acid calcium salt
CAS 1492-18-8
Assay 97.0-102.0%
Packing 25kg/drum

Calcium folinate

NameCalcium folinate
SynonymsFolinic acid calcium salt
                             Molecular StructureCAS # 1492-18-8, Calcium folinate, Folinic acid calcium salt, N-(4-(((2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt
Molecular FormulaC20H21N7O7.Ca
Molecular Weight511.51
CAS Registry Number1492-18-8
EC Number216-082-8

Specification:

Items

Specifications

Appearance

White or light yellow hygroscopic powder

Identification IR

Conforms to the Reference Spectrum

Calcium salt

must give a positive reaction

Appearance of solution

Clear and colorless

PH

7.5-8.5

Residue on ignition

Ethanol

3.0%

Acetone

≤0.5%

Methanol

0.3%

Related substances

Impurity A

0.3%

Impurity E

0.3%

Impurity F

0.2%

Impurity I

0.2%

Impurity H

0.5%

Unknown impurities

0.2%

Total impurities

1.5%

Chloride (Cl)

0.5%

Water

10.0%-17.0%

Heavy metals

50 ppm

Calcium

7.54%-8.14%

Calcium folinate

97.0-102.0%

Total aerobic microbial count

≤1000cfu/g

Total combined yeast and mold count

≤100cfu/g

Escherichia coli

Absent/g

Salmonella

Absent/g

S.aureus

Absent/g

Uses:

1. Detoxification effect

Methotrexate detoxification

Detoxification with other folate antagonists

2. Tumor treatment adjuvant

Enhance chemotherapy efficacy

Preventing bone marrow suppression

3. Treatment of hematological diseases

Megaloblastic anemia

4. Other uses

Prevention of Fetal Neural Tube Defects

Cardiovascular protection

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